I used this code that seems to do the trick: import pyodbc conn = pyodbc.connect( 'driver={ODBC Driver 17 for SQL Server};' 'server=XXXXXXXXXX;' 'database=YYYYYY;' 'uid=ZZZZZZ;' 'pwd=QQQQQQQQ;' ) rs = conn.cursor() rs.execute( ''' INSERT INTO quant_test (symbol,stockprice) VALUES ('AAPL',180) ''' ) conn.commit() rs.execute(''' INSERT INTO quant_test (symbol,stockprice) VALUES ('AAPL',180) ''') conn.commit()